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Brian Smith

Brian Smith

Founder and managing director at S3 Ventures; director at VahatiCor.

DirectorPublic companyRoles at 4 startups
Updated Nov 9, 2026·Latest SEC filing Oct 20, 2026·Suggest an edit

About Brian Smith

Brian R. Smith founded S3 Ventures and is its managing director. The firm backs business and health care technology companies. He is a VahatiCor director. VahatiCor develops a heart implant for people with coronary microvascular dysfunction.

At 29, Smith founded Crossroads Systems and became its chairman and chief executive officer. He took it public in 1999 and ran the public company for almost four years. Earlier, he spent seven years in product development at IBM. He holds engineering degrees from the University of Cincinnati and Purdue University. He received an Ernst & Young Entrepreneur of the Year award in 2000. His current boards include Alkami Technology and Alleviant Medical. Earlier seats include Acessa Health and TVA Medical.

Experience

This experience comes from official bios and from SEC filings. For roles taken from filings, the years are when the filings name Brian Smith in the role, so the role may have started earlier or lasted longer.

VahatiCor, Inc. Current
Founder and Managing Director, S3 Ventures
2025 – Present · Santa Clara, CA
It is testing a catheter-delivered implant designed to redirect heart blood flow and relieve persistent chest pain.
Alleviant Medical, Inc. Current
Director
2023 – Present · Austin, TX
Alkami Technology, Inc. Current
Director and 10% owner
2021 – Present · Public company (ALKT)
S3 Ventures Current
Founder and Managing Director
Endovascular Engineering Current
Board member
Flex Vascular Current
Board member
Folia Current
Board member
Liquibase Current
Board member
Medical Micro Current
Board member
VUV Analytics Current
Board member
Versa Vascular Current
Board member
MaxQ Medical Inc.
Director
2026 · Sunnyvale, CA
Develops a prostate imaging and treatment system for urologists.
SpectraWAVE, Inc.
Director
2024 · Bedford, MA
Crossroads Systems
Chairman and CEO
IBM Corporation
Acessa Health
Board member
Briggo
Board member
Favor
Board member
Gravitant
Board member
LibreDigital
Board member
Packet Design
Board member
Phurnace
Board member
Sipera System
Board member
StoredIQ
Board member
Tango Health
Board member
TVA Medical
Board member

Key Colleagues at Startups

The people Brian Smith works with at each company, as listed on that company's latest Form D.

VahatiCor, Inc. · Form D/A, Oct 20, 2026
Harry Rowland
Harry Rowland
CEO and director
MS
Marwan Berrada-Sounni
FOUNDER and CHAIRMAN
Bruce Samuels
Bruce Samuels
Interventional Cardiologist, Cedars-Sinai Medical Center, Board Member
MaxQ Medical Inc. · Form D, Aug 19, 2026
Amir Abolfathi
Amir Abolfathi
Executive Chairman
JI
AT
Amir Tehrani
CEO and director
DR
Dean Riskas
Director
Alleviant Medical, Inc. · Form D, Jan 27, 2025
GP
Geoff Pardo
Director
IM
Ian Meredith
Director
MB
AB
Adam Berman
CEO and director
KN
Kirk Nielsen
Director
JS
SpectraWAVE, Inc. · Form D/A, Oct 15, 2024
EN
Eman Namati
CEO and director
PL
GB
Gerry Brunk
Director
BL
Bill Little
Director

Brian Smith in the News

Sources

  1. SECVahatiCor, Inc. Form D/A, filed Oct 20, 2026
  2. SECMaxQ Medical Inc. Form D, filed Aug 19, 2026
  3. SECAlleviant Medical, Inc. Form D, filed Jan 27, 2025
  4. SECSpectraWAVE, Inc. Form D/A, filed Oct 15, 2024
  5. SECForms 3, 4 and 5 filed by Brian Smith (SEC filer 1106642)
  6. P2VahatiCor Series B release