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Lou Tartaglia

Lou Tartaglia

Crosslink director and Cure Ventures managing partner and co-founder

Director
Updated Nov 8, 2026·Latest SEC filing Oct 20, 2026·Suggest an edit

About Lou Tartaglia

Lou Tartaglia is a Crosslink director and a managing partner and co-founder of Cure Ventures. Crosslink develops cancer medicines that assemble in solid tumors. His biotech career spans more than 30 years across science, product development, and venture investing. In 2016, he ran 5AM Ventures' 4:59 company-building effort and led the formation of Entrada Therapeutics. He then served as Entrada's interim chief executive for its first year. Later, he became a 5AM venture partner and took chief executive roles at startups.

He held two vice president roles at Millennium Pharmaceuticals from 1993 to 2004. From 2004 to 2007, he was Gene Logic's senior vice president and general manager. He joined Third Rock Ventures as a partner in 2007. As of June 2014, he had served on Zafgen's board since October 2007. He holds a doctorate in biochemistry from UC Berkeley and a bachelor's in chemistry from the University at Albany.

Experience

This experience comes from official bios, from Lou Tartaglia's profile and from SEC filings. For roles taken from filings, the years are when the filings name Lou Tartaglia in the role, so the role may have started earlier or lasted longer.

Crosslink Therapeutics Inc. Current
Director
2025 – Present · Boston, MA
Crosslink builds a modular biologic platform for antibody-drug conjugates and radioligand therapies.
Cure Ventures Current
Managing Partner and Co-Founder
5AM Ventures
Venture Partner
Head of 4:59 (2016)
2016
Entrada Therapeutics
interim CEO
From 2016
Solstice Biologics
CEO
2014 – 2015
Third Rock Ventures
partner
From 2007
Zafgen, Inc.
member of our board of directors
From 2007
Gene Logic
senior vice president and general manager
2004 – 2007
Millennium Pharmaceuticals
vice president of new ventures and vice president of metabolic diseases
1993 – 2004
Genentech
Postdoc
1990 – 1993

Key Colleagues at Startups

The people Lou Tartaglia works with at each company, as listed on that company's latest Form D.

Crosslink Therapeutics Inc. · Form D, Oct 20, 2026
RI
Ronald Seidel, III
Co-founder and CEO, director
AK
Andrew King
Director
Rodolfo Chaparro
Rodolfo Chaparro
Co-Founder and Scientific Advisor, director

Sources

  1. SECCrosslink Therapeutics Inc. Form D, filed Oct 20, 2026
  2. P2About Crosslink
  3. P4Zafgen filing