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Manny Villafana

Manny Villafana

Founder, chairman and chief executive officer of Medical 21

ExecutiveDirector
Updated Nov 9, 2026·Latest SEC filing Oct 23, 2026·Suggest an edit

About Manny Villafana

Manny Villafaña is the founder, chairman and chief executive officer of Medical 21, and a director. Medical 21 develops vascular graft technology for people who have coronary artery bypass surgery. It is his eighth medical device company. He led the earlier seven to IPO financing.

Villafaña began as a sales representative at Picker International in 1964. By 1967 he worked at Medtronic, where he was the first international sales administrator for the pacemaker. He founded Cardiac Pacemakers, Inc. (Guidant Corp) and was its president and chairman from 1972 to 1976. He founded St. Jude Medical, Inc. and was its chairman and president from 1976 to 1982. He founded ATS Medical, Inc. in 1990 and was chairman of its board. ATS is now part of Medtronic. He co-founded GV Medical, Inc., and chaired its board and the board of CABG Medical, Inc. In 2007 he founded Kips Bay Medical, Inc.

Experience

This experience comes from official bios and from SEC filings. For roles taken from filings, the years are when the filings name Manny Villafana in the role, so the role may have started earlier or lasted longer.

Medical 21, Inc. Current
Founder & CEO, director
Founder, Chairman & CEO
2016 – Present · Plymouth, MN
Medical 21 is developing a regenerative graft meant to replace harvested veins in coronary artery bypass surgery.
Kips Bay Medical, Inc.
Chairman, Chief Executive Officer, Chief Financial Officer, Secretary
From 2007
ATS Medical
Founder
From 1990
St. Jude Medical, Inc.
Founder
From 1976
CPI/Guidant
Founder
From 1972

Key Colleagues at Startups

The people Manny Villafana works with at each company, as listed on that company's latest Form D.

Medical 21, Inc. · Form D, Oct 23, 2026
ES
Eric Solien
Vice President, Clinical Sciences
JV
Jeff Vreeman
Vice President, Manufacturing
AS
Andrea Sweeney
Vice President, Business Administration

Manny Villafana in the News

Sources

  1. SECMedical 21, Inc. Form D, filed Oct 23, 2026
  2. teamTeam — Medical 21
  3. bioOur Founder: Manny Villafaña — Kips Bay Medical
  4. secKips Bay Medical, Inc. S-1/A, Exhibit 10.2 (Investment Agreement)