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Steven Altschuler

Steven Altschuler

Chief executive officer and director of ai3Bio

ExecutiveDirectorPublic companyRoles at 2 startups
Updated Nov 9, 2026·Latest SEC filing Nov 4, 2026·Suggest an edit

About Steven Altschuler

Steve Altschuler is chief executive officer and a director of ai3Bio, a company developing lipid nanoparticle and antibody treatments meant to remove the immune cells that drive autoimmune disease. He is also managing director of Healthcare Ventures at Ziff Capital Partners, an investment firm that funds and helps build biotechnology companies focused on cellular and molecular approaches to disease. He currently serves as board chair of 89Bio, Lexeo Tx, Port Tx and Avista Tx.

He formerly held chief executive positions at Children's Hospital of Philadelphia and the University of Miami Health System. He co-founded Spark Therapeutics and served as its board chair from the company's founding until its acquisition in 2019. He is a board member of WW, ImVaX and Stellular Bio. He is also a trustee of the POLG Foundation and the Institute of Innovative Genomics at the University of California, Berkeley.

Experience

This experience comes from official bios and from SEC filings. For roles taken from filings, the years are when the filings name Steven Altschuler in the role, so the role may have started earlier or lasted longer.

AI3 Bio, Inc. Current
CEO, Board Director
Chief Executive Officer
2024 – Present · Watertown, MA
ai3Bio develops lipid nanoparticle and antibody drugs that remove the T cells driving autoimmune disease, for patients living with these conditions.
89bio, Inc. Current
board chair
2020 – Present · Public company (ETNB)
WW International, Inc. Current
Director
2012 – Present · Public company (WW)
Ziff Capital Partners Current
managing director of Healthcare Ventures
ImVaX Current
member of the board of directors
Stellular Bio Current
member of the board of directors
Lexeo Tx Current
board chair
Port Tx Current
board chair
Avista Tx Current
board chair
POLG Foundation Current
trustee
Institute of Innovative Genomics, University of California, Berkeley Current
trustee
Lexeo Therapeutics, Inc.
Director
2023 – 2026 · Public company (LXEO)
AsclepiX Therapeutics, Inc.
Director
2019 – 2024 · Bethesda, MD
Orchard Therapeutics plc
Director
2020 – 2024 · Public company (ORTX)
Spark Therapeutics, Inc.
Director and 10% owner
board chair (2019)
2015 – 2019 · Public company (ONCE)
Covista Inc.
Director
2018 – 2019 · Public company (CVSA)
Mead Johnson Nutrition Co
Director
2009 – 2017 · Public company (MJN)
Children's Hospital of Philadelphia (CHOP)
chief executive
University of Miami Health System
chief executive

Key Colleagues at Startups

The people Steven Altschuler works with at each company, as listed on that company's latest Form D.

AI3 Bio, Inc. · Form D, Nov 4, 2026
ML
Michael Lyman
Executive officer
NS
Nick Seaver
CFO/CBO, Board Director
AE
Alan Ezekowitz
Board Director
Jonathan Kagan
Jonathan Kagan
Distinguished Scientist
AsclepiX Therapeutics, Inc. · Form D, Apr 26, 2024
RD
Robert Dempsey
Chief Executive Officer
BA
Ben Askew
Director
JB
Josh Barer
Director
AP
Aleksander Popel
Executive officer
AS
Amir Shojaei
Executive officer
NP
Niranjan Pandey
Executive officer
JT
Jill Tierney
Executive officer
JG
Jordan Green
Director

Sources

  1. SECAI3 Bio, Inc. Form D, filed Nov 4, 2026
  2. SECAsclepiX Therapeutics, Inc. Form D, filed Apr 26, 2024
  3. SECForms 3, 4 and 5 filed by Steven Altschuler (SEC filer 1458116)
  4. releaseai3Bio Series A launch release